| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1964787 | Cellular Signalling | 2010 | 7 Pages |
Abstract
We propose a model, in which the Ca2+ binding at the EEEE motif and the consequent conformational changes in the channel are the primary event in triggering secretion, while synaptotagmin acts as a vesicle docking protein. Thus, the channel serves as the molecular On/Off signaling switch, where the predominance of a conformational change in Ca2+-bound channel provides for the fast secretory process.
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Authors
Daphne Atlas,