Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1965077 | Clinica Chimica Acta | 2016 | 6 Pages |
Abstract
We identified and characterized a novel intronic mutation in the MSX1 gene in a large Chinese pedigree, adding to the small repertoire of MSX1 mutations associated with autosomal dominant tooth agenesis. We hypothesize that the variable degree of tooth agenesis observed in each affected individual may be due to sub-optimal levels of MSX1 expression during critical stages tooth development.
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Authors
Jinjie Xue, Qingping Gao, Yanru Huang, Xiaoyu Zhang, Pu Yang, David S. Cram, Desheng Liang, Lingqian Wu,