Aberrant de novo cholesterogenesis: Clinical significance and implications

•The present review focuses on current understanding of de novo cholesterogenesis.•Various genetic, environmental and dietetic factors affecting de novo cholesterogenesis are discussed.•Present review also highlights the deregulations of this pathway in various physiological and pathological conditions.

Human cells can acquire cholesterol from the circulation but also have the ability to synthesize it via de novo cholesterogenesis (DC). Cholesterol absorption and de novo cholesterogenesis are the key processes that modulate cholesterol homeostasis in the human body. The endogenous biosynthesis of cholesterol substantially contributes to the whole-body cholesterol pool. Additionally, dysregulation of this pathway is associated with diverse medical conditions. The present review focuses on our current understanding of the cholesterogenic pathway and the various different factors regulating this pathway. It also highlights dysregulation of this pathway in various physiological and pathological conditions including cardiovascular diseases, type II diabetes, obesity and viral infections.