| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1966495 | Clinica Chimica Acta | 2009 | 5 Pages |
BackgroundIschemia modified albumin (IMA), is a new biomarker of oxidative processes involved with coronary artery disease (CAD). We determined serum IMA, high-sensitivity C-reactive protein (hsCRP), and natriuretic peptide (NT-proBNP), and evaluated their correlation with severity of coronary atherosclerosis in patients undergoing coronary angiography (CA). Cardiac troponin T (cTnT), CK-MB mass, albumin and Total Antioxidant Status (TAS) were also evaluated.MethodsThe study included 114 patients (88 men and 30 women) aged 43–80 years with documented CAD without evidence of acute coronary syndrome undergoing CA and 163 controls (131 men and 32 women) similarly aged.ResultsIMA, hsCRP and NT-proBNP were higher (p < 0.001 and p = 0.008 for NT-proBNP) while TAS was lower (p < 0.001) in patients than in controls. IMA and TAS were negatively correlated in all subjects (p < 0.01). Among patients, there was no correlation between IMA and the number of diseased vessels. For CAD diagnosis the best cut-off point for IMA was 101.5 KU/L with a sensitivity and a specificity of 87.7% and a negative predictive value of 83.3%. IMA was associated with an increased risk for CAD (OR = 1.23, 95% CI: 1.16–1.31; p < 0.001).ConclusionsIMA determination may provide earlier information of CAD presence before hsCRP or NT-proBNP elevation, contributing to early assessment of overall patient risk.
