Article ID Journal Published Year Pages File Type
1966656 Clinica Chimica Acta 2009 5 Pages PDF
Abstract

BackgroundMonocyte chemoattractant protein-1 (MCP-1) plays a role in adipose tissue inflammation and insulin resistance. Human circulating MCP-1 concentrations reportedly increase or remain unchanged according to obesity or insulin resistance in various ethnic populations; whether or not circulating MCP-1 concentrations increase after menopause has remained unclear.MethodsWe investigated the relationship between circulating MCP-1 concentrations and obesity or insulin resistance, and the relationship between circulating MCP-1 and menopause status in premenopausal (n = 111) and postmenopausal (n = 64) Korean women.ResultsCirculating MCP-1 concentrations were significantly higher in postmenopausal women than in obesity-matched premenopausal women; they did not differ between non-obese and obese subgroups of pre- and postmenopausal women. Circulating MCP-1 concentrations had a relationship with menopause status (ρ = 0.500, p = 0.000), irrespective of obesity, but no relationship with obesity or insulin resistance. Circulating MCP-1 concentrations correlated with serum triglycerides (r = 0.4, p = 0.001) and also correlated with serum triglyceride concentrations, after adjusting for age and obesity, in postmenopausal women.ConclusionsCirculating MCP-1 concentrations are associated with menopause status itself, irrespective of obesity; they do not correlate with obesity or insulin resistance in Korean women, most of whom are not severely obese.

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