Increased expression of SRp40 affecting CD44 splicing is associated with the clinical outcome of lymph node metastasis in human breast cancer

Increased expression of SRp40 can be detected in breast tumor tissues with a high degree of sensitivity, and that higher expression of SRp40 closely correlates with alternative pre-mRNA splicing of CD44, which may serve as an earlier marker in predicting the risk to breast cancer patients of developing LNM.