| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1968 | Acta Biomaterialia | 2008 | 9 Pages |
Abstract
We describe here the chemical synthesis and in vitro drug delivery response of polyethylene glycol (PEG)-functionalized magnetite (Fe3O4) nanoparticles, which were activated with a stable ligand, folic acid, and conjugated with an anticancer drug, doxorubicin. The functionalization and conjugation steps in the chemical synthesis were confirmed using Fourier transform infrared spectroscopy. The drug-release behavior of PEG-functionalized and folic acid–doxorubicin-conjugated magnetic nanoparticles was characterized by two stages involving an initial rapid release, followed by a controlled release.
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Authors
J. Zhang, S. Rana, R.S. Srivastava, R.D.K. Misra,