Pro-inflammatory states and IGF-I level in ischemic heart disease with low or high serum iron

The IHD patients with low serum iron were associated with a pro-inflammatory state, such as increased TNF-α, IL-6, and hsCRP; increased anti-inflammatory activities, such as increased IL-10; decreased cardiac protective factor, such as decreased IGF-I. These findings may imply that IHD patients with low serum irons were associated with less cardiac protection and more pro-inflammatory states than normal subjects or IHD patients with either normal or high serum iron.