| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1968653 | Clinical Biochemistry | 2013 | 4 Pages |
•CYP1B1 gene is involved in estrogen hormone synthesis and xenobiotic metabolism.•Homozygous variant of CYP1B1*2 was significantly higher in PTL cases.•Heterozygous variant of CYP1B1*3 and CYP1B1*7 genes were significantly higher in PTL cases.•CYP1B1 gene polymorphism have shown the genetic susceptibility to PTL.
ObjectiveThe etiology of preterm labor (PTL) is still unknown, but it may be related to a possible genetic predisposition together with involvement of environmental factors. We investigated the relation between PTL and polymorphisms in Cytochrome P4501B1 (CYP1B1) gene, which is involved in the metabolism of a wide range of environmental toxins and hormones.Design and methodsThree hundred (n = 300) cases of PTL and equal number of subjects of full term labor (FTL), after excluding all the known risk factors for PTL were included in the study. A two step allele specific PCR was performed for polymorphic analysis of CYP1B1 gene.ResultsThe homozygous variant genotype of CYP1B1*2 (OR = 2.97, 95%CI = 1.08–8.08, p = 0.033) and heterozygous variant of CYP1B1*3 (OR = 2.57, 95%CI = 1.88–3.63, p = 0.001), and CYP1B1*7 (OR = 2.59, 95%CI = 1.85–3.62, p = 0.001) were found to be significantly higher in PTL cases as compared to FTL.ConclusionsThe present study demonstrates the possible association of homozygous variant of CYP1B1*2 and heterozygous variant of CYP1B1*3 and CYP1B1*7 genes with the increased risk of PTL.
