| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1968963 | Clinical Biochemistry | 2013 | 4 Pages |
BackgroundWhole blood viscosity (WBV) is the resistance of blood flow in blood vessels. Increased WBV may be a cardiovascular risk factor. The proper screening of WBV can help the early detection of cardiovascular disease. We investigated the performance of a new scanning capillary tube viscometer (SCTV) for the measurement of WBV.MethodsWe evaluated the total precision of the SCTV for 20 days using three control viscosity materials, and the within-day precision with the whole blood samples of three different individuals. For the linearity evaluation, serial dilutions of a high concentration standard material were used. For the method comparison, the results of the SCTV method were compared to those of Brookfield rotating viscometer on 227 subjects.ResultsThe SCTV had good within-run and total-run coefficient of variant (CV)s at low-, medium-, and high-concentration samples, at shear rates of 1 and 300 s− 1. The within-day CVs with the three human blood samples were 6.3%, 3.7% and 3.8% at a shear rate of 1 s− 1, and 3.2%, 3.0% and 4.1% at a shear rate of 300 s− 1. The SCTV method showed an excellent linearity in the range of 84.9 to 558.2 milliPoise (mP) and 28.8 to 71.0 mP at shear rates of 1 and 300 s− 1, respectively. For the comparison study, the SCTV and the rotating viscometer showed comparable results.ConclusionsThe SCTV showed a stable analytical performance, and was comparable with the rotational viscometer. This new SCTV method can be used in the clinical laboratory for various needs.
► We investigated the performance of a new scanning capillary tube viscometer (SCTV) with the Clinical Laboratory and Standards Institute (CLSI). ► The SCTV showed excellent within-run CVs, between-run, between-day, and total-run CVs at the low-, mid-, and high-concentration samples at high and low shear rate. ► The SCTV was linear over the entire range tested with good recovery at high and low shear rate. ► The WBV using the SCVT showed comparable results with the Brookfield viscometer.
