Prooxidant–anti-oxidant balance is not associated with extent of coronary artery disease

ObjectiveWe have measured the pro-oxidant–antioxidant-balance (PAB) levels in patients with defined coronary artery disease (CAD) and compared them with concentrations in healthy subjects.Design and methodsBased on angiography results, 400 patients with stable CAD were divided into CAD− and CAD+, this being further subcategorized into groups with single-, double- and triple-vessel disease (VD).ResultsThe mean PAB values in the healthy subjects, was significantly lower than for other groups (P < 0.001). In CAD− patients, PAB levels were 123.2 ± 43.9, which was not statistically different compared to groups with SVD, 2VD and 3VD (P > 0.05). In the CAD+ group, PAB values in 1VD, 2VD and 3VD were not significantly different among patients with SVD, 2VD and 3VD (P > 0.05).ConclusionsIn conclusion, we found higher levels of oxidative stress in CAD+ patients compared to healthy subjects. The oxidation level was not related to measures of the extent of CAD such as number of stenosed vessels.

► The serum prooxidant-anti-Oxidant balance (PAB) is higher in patientswith CAD. ► Angiographically defined extent of CAD is not related to the serum PAB. ► Gender and serum HDL-cholesterol were associated with serum PAB levels.