| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1969310 | Clinical Biochemistry | 2012 | 5 Pages |
ObjectivesThe aim of the present study was to investigate the association between CCR2-Val64Ile and CCR5-Δ32 variants and the estimation of haplotypes with MI in a sample of the Tunisian population.Design and methodsA total of 290 unrelated MI patients and 282 healthy controls were studied. The CCR2-Val64Ile and CCR5-Δ32 variants were analyzed by PCR-RFLP.ResultsSubjects carrying at least one copy of the CCR5-deletion allele were significantly more common in the control group, suggesting an atheroprotective effect (adjusted OR = 0.44, 95% CI = 0.28–0.72, p = 0.001). Haplotype analysis showed that MI patients had significantly less 64Val-Del haplotype (9.9% vs. 21.3%, OR = 0.30, 95% CI = 0.21–0.43, p < 0.001) and 64Ile-Ins haplotype (12.3% vs. 16.7%, OR = 0.58, 95% CI = 0.42–0.80, p < 0.001).ConclusionA protective effect of the CCR5-Δ32 polymorphism against MI in the Tunisian population was found.
► This study included 290 unrelated patients with MI and 282 healthy subjects. ► We investigated association between the CCR2 and CCR5 variants and MI in Tunisians. ► These polymorphisms were determined in all participants by PCR-RFLP analysis. ► Genotype distribution of the CCR5-D32 variant was different between MI and controls. ► CCR2-Val64Ile polymorphism was not significantly associated with MI.
