| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1969315 | Clinical Biochemistry | 2012 | 5 Pages |
ObjectivesCoronary artery disease (CAD) has emerged as the major cause of morbidity and mortality among Asian Indians in the recent past. The following study was undertaken to assess the predictive value of novel biomarkers of dyslipidemia for risk assessment for CAD in the Indian population.Design and methodsThe study group comprised of 100 clinically assessed patients of myocardial infarction and 100 age and sex matched healthy controls. Apolipoprotein-A (Apo-AI) and Apolipoprotein-B (Apo-B) were estimated and small dense LDL was derived mathematically.ResultsThe cases showed significantly high levels of total serum cholesterol, triglycerides, LDL cholesterol, Apo-B, sdLDL, and non-HDL cholesterol. On carrying out multivariate regression analysis, Lp(a)/HDL ratio emerged as the best determinant of CAD riskConclusionThe above data clearly underlines the role of these novel biomarkers in the risk assessment for CAD in the Indian context.
► CAD is the main cause of morbidity and mortality. ► Asian Indians are predisposed to CAD due to their unique genetic and environmental predisposition. ► Lipids are the mainstay of risk assessment for cardiovascular disorders. ► The paper highlights the utility of various lipid ratios and indices in risk stratification. ► The ratio Lp(a)/HDL emerges as the best biomarker. ► This will prove beneficial in screening protocols.
