| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1969514 | Clinical Biochemistry | 2012 | 4 Pages |
ObjectivesThe purpose of this study was to evaluate the effects of interleukin-13 (IL-13) polymorphisms on the risk of asthma using a meta-analysis.Design and methodsFifteen publications were identified by searching Pubmed, Embase, ISI, OVID, and EBSCO databases. Odds ratios with corresponding 95% confidence intervals were computed to estimate the association between IL-13 polymorphisms and risk of asthma.ResultsThe polymorphisms of R130Q (rs20541) and -1112C/T (rs1800925) in IL-13 gene were associated with significantly increased risks of asthma in overall analyses. Subgroup analyses showed that the elevated risks occurred in adult-onset asthma, Caucasians, and high quality studies.ConclusionsThis meta-analysis provides evidence that the R130Q and -1112C/T polymorphisms in IL-13 are risk factors for asthma.
► Association between IL-13 polymorphisms and asthma risk was examined using meta-analysis. ► The polymorphisms of R130Q and -1112C/T in IL-13 gene increased asthma risk. ► IL-13 polymorphisms are risk factors for asthma.
