The role of bone turnover markers in monitoring treatment in postmenopausal osteoporosis

Bone metabolism is assessed using biochemical bone turnover markers (BTM). BTM reflect the metabolic effect of drugs on bone turnover, help to establish the lowest dose inducing the largest change in the BTM, predict treatment-related reduction in fracture risk, and are helpful in bridging studies. Changes in BTM during anti-osteoporotic therapy depend on the cellular mechanism of action of the drug, degree of change in bone turnover rate and route of administration. BTM help to establish the optimal dose of anti-osteoporotic drugs because treatment-related changes in BTM are more rapid compared with change in BMD. A greater decrease in BTM levels during the first year of tantiresorptive treatment is associated with greater antifracture efficacy over 3 years. According to preliminary data, measurement of BTM can improve persistence with anti-resorptive treatment. The use of BTM to monitor anti-osteoporotic therapy in “real life” is limited at this stage.

► Biochemical bone turnover markers (BTM) reflect the effect of drugs on bone turnover. ► BTM help to establish the dose and predict therapy-induced reduction in fracture risk. ► Measurement of BTM may improve persistence with anti-resorptive treatment. ► The use of BTM to monitor anti-osteoporotic therapy in “real life” is limited at this stage.