Association of follicle-stimulating hormone and sex hormone binding globulin with the metabolic syndrome in postmenopausal women

ObjectivesWe compared the association of follicle-stimulating hormone (FSH) and sex hormone binding globulin (SHBG) with metabolic syndrome (MetS).Design and methodsWe examined 320 postmenopausal women (148 with MetS and 172 without MetS).ResultsFSH was more strongly associated with MetS probability in the logistic regression model compared to SHBG. Receiver operating characteristic (ROC) curves comparison showed greater areas under the curve for FSH than SHBG concentrations.ConclusionsFSH exhibited a stronger coherence to MetS than SHBG in postmenopausal women.

► We compared the association of FSH and SHBG with metabolic syndrome. ► We examined 320 postmenopausal women aged 46–60 years. ► FSH was more strongly associated with metabolic syndrome compared to SHBG.