Development of a novel microarray methodology for the study of SNPs in the promoter region of the TNF-α gene-Their association with obstructive pulmonary disease in Greek patients

Genotype frequencies of the 5 SNPs showed no significant difference between the COPD and DB patient groups and the healthy smokers group. Statistical difference (p = 0.043) was only revealed between the haplotype frequencies in COPD patients compared to the general population control group. The NanoChip™ MBW is an accurate method for SNP screening.