| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1970824 | Clinical Biochemistry | 2011 | 5 Pages |
ObjectivesDeficiency and/or decreased activity of methyltetrahydrofolate reductase (MTHFR) resulted from MTHFR variants are associated with hyperhomocysteinemia, an independent risk factor for vasculopathies in diabetic patients. The aim of this study was to examine MTHFR genotypes between healthy and type 2 diabetes mellitus (T2DM) subjects.Design and methodsMTHFR C677T and A1298C genotypes were analyzed in 56 T2DM and 62 healthy subjects by PCR-RFLP. Association between MTHFR genotypes and T2DM as well as the lipid/glucose metabolic indexes among T2DM subjects was statistically analyzed.ResultsNo significance in the distribution of MTHFR genotypes between healthy and T2DM subjects is found. Besides, no significant associations between lipid/glucose metabolic indexes with MTHFR genotypes among diabetic patients are observed.ConclusionsThese data indicate the previous observation that MTHFR polymorphisms may play some roles in the pathogenesis and complications of T2DM in Caucasians are unlikely to be applied in Taiwanese patients.
► The study is to examine the MTHFR genotypes among healthy and T2DM subjects. ► MTHFR C677T and A1298C SNPs were analyzed in 56 T2DM and 62 healthy subjects. ► Distribution of MTHFR SNPs between control and T2DM is not significantly different. ► Roles of MTHFR in Caucasian T2DM are unlikely to be applied in Taiwanese population.
