Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1971324 | Clinical Biochemistry | 2008 | 4 Pages |
The MTG-BT estimates the hydrolysis of triacyl-glycerols by pancreatic lipase, and appears attractive for monitoring exogenous lipase requirements in patients with exocrine pancreatic insufficiency. To assess the test's discrimination capacity and repeatability, 9 CF patients with PERT and 10 healthy children underwent the 13C-MTG-BT twice, at a 2- to 4-week interval. The test distinguished well between patients with severe exocrine pancreatic insufficiency (SEPI) and healthy subjects. However, within-subject variability for postprandial ‰13C-enrichment and postprandial % dose recovery (PDR) was high in both groups. Therefore, the 13C-MTG-BT seems useful to distinguish between SEPI and normal exocrine pancreatic function, but requires further development to improve its repeatability.