Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1975027 | Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology | 2016 | 4 Pages |
Abstract
Soluble leptin receptor (sLepR) is the main leptin-binding protein in plasma and contributes to activation of circulating leptin. In this study, we identified a sLepR in plasma of crucian carp (Carassius carassius) using a pull-down assay, and the interaction of sLepR with its ligand is confirmed by a cross-linking study. In addition, we found that leptin-a has higher affinity than leptin-b for sLepR. According to our knowledge, this is the first experimental report about the main ligand of sLepR in teleost.
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Authors
Feifei Xie, Xin Li, Saifan Huang, Jiyuan Li, Xiaopin Guo, Yibin Cao,