| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1979077 | Current Opinion in Structural Biology | 2012 | 11 Pages |
Abstract
► Mg2+ is a uniquely suited partner for RNA due to its ability to localize water molecules and pack RNA phosphate groups. ► Current and past work supports the ubiquity of Mg2+, both diffuse and coordinated, in RNA folding and catalysis. ► Review of recent literature reveals inaccuracy in the treatment of RNA-divalent cation interactions in theoretical models. ► A general conceptual framework of cation-RNA interactions is presented, which links thermodynamics and structure. ► Examples of new applications of previous methods and new methods for studying RNA-cation relationships are described.
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Authors
Jessica C Bowman, Timothy K Lenz, Nicholas V Hud, Loren Dean Williams,