| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1979086 | Current Opinion in Structural Biology | 2012 | 9 Pages |
Abstract
⺠Domain rearrangements of â¼100 Ã
underlie regulation of complement protease cascade. ⺠Allosteric auto-activation of C1/MBL-associated modular proteases upon microbe binding. ⺠Structures of factor B, D, CVFB, C3bB and C3bBD reveal C3 convertase formation. ⺠Substrate-product (C3-C3b) binding drives C3 convertase in complement amplification. ⺠Regulators bind C3b to decay and degrade convertases to protect hosts.
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Authors
Federico Forneris, Jin Wu, Piet Gros,