Towards a molecular view of transcriptional control

The accumulation of experimental data over recent years has fueled theoretical work on how transcription factors (TFs) search for and recognise their DNA target sites, how they interact with one another, or with other DNA-binding proteins, and how they cope with the compaction of DNA within bacterial nucleoids or within eukaryotic chromatin. Many models have been built to study the kinetic, thermodynamic and mechanistic aspects of these questions. In some cases they have resulted in a relatively clear consensus view, but a number of questions remain controversial. We present an overview of recent work, with an emphasis on models that provide, or can inspire, a better understanding of transcriptional control at a detailed molecular level.

► We review the components of transcriptional control. ► We summarise transcription factor search mechanisms. ► We contrast models with various levels of molecular detail.