Article ID Journal Published Year Pages File Type
1979196 Current Opinion in Structural Biology 2012 10 Pages PDF
Abstract
► Molecular simulations have revisited the original stalk-pore hypothesis. ► Initial membrane merger is determined by the free energy of leaflet approach. ► SNARE complexes reduce the free energy of leaflet approach and are actively involved in the lipidic transition states. ► SNARE complexes release mechanical stress to actively overcome the barrier against stalk expansion and enforce opening of the fusion pore. ► SNARE complexes can prevent the formation/expansion of a metastable hemifusion diaphragm.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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