Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1979196 | Current Opinion in Structural Biology | 2012 | 10 Pages |
Abstract
⺠Molecular simulations have revisited the original stalk-pore hypothesis. ⺠Initial membrane merger is determined by the free energy of leaflet approach. ⺠SNARE complexes reduce the free energy of leaflet approach and are actively involved in the lipidic transition states. ⺠SNARE complexes release mechanical stress to actively overcome the barrier against stalk expansion and enforce opening of the fusion pore. ⺠SNARE complexes can prevent the formation/expansion of a metastable hemifusion diaphragm.
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Authors
Herre Jelger Risselada, Helmut Grubmüller,