Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1979283 | Current Opinion in Structural Biology | 2009 | 10 Pages |
Abstract
The ebolavirus (EBOV) envelope glycoprotein (GP) is solely responsible for viral attachment to, fusion with, and entry of new host cells, and consequently is a major target of vaccine design efforts. Recently determined crystal structures of key antibodies in complex with their EBOV epitopes have provided insights into the molecular architecture of GP and defined likely hotspots for viral neutralization. In this review, we discuss the structural basis for antibody-mediated neutralization of ebolavirus and its implications for novel therapeutic or vaccine strategies.
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Authors
Jeffrey E Lee, Erica Ollmann Saphire,