Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1979446 | Current Opinion in Structural Biology | 2011 | 9 Pages |
Abstract
Nine different near-atomic resolution structures of icosahedral viruses, determined by electron cryo-microscopy and published between early 2008 and late 2010, fulfil predictions made 15 years ago that single-particle cryo-EM techniques could visualize molecular detail at 3–4 Å resolution. This review summarizes technical developments, both in instrumentation and in computation, that have led to the new structures, which advance our understanding of virus assembly and cell entry.
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Authors
Nikolaus Grigorieff, Stephen C Harrison,