Article ID Journal Published Year Pages File Type
1979511 Current Opinion in Structural Biology 2007 7 Pages PDF
Abstract

Membrane proteins perform crucial communication functions across biological membranes. They represent important targets for therapies and have unique properties for biotechnological applications. Recently, the number of high-resolution membrane protein structures has significantly increased and new insights into the sequence/structure relationships of transmembrane helical assemblies have been gained. Together with new experimental techniques, these advances have improved our understanding of membrane protein folding, stability, and recognition. Consequently, new design strategies are emerging that aim to target and stabilize simple transmembrane helical interfaces.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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