Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1979511 | Current Opinion in Structural Biology | 2007 | 7 Pages |
Abstract
Membrane proteins perform crucial communication functions across biological membranes. They represent important targets for therapies and have unique properties for biotechnological applications. Recently, the number of high-resolution membrane protein structures has significantly increased and new insights into the sequence/structure relationships of transmembrane helical assemblies have been gained. Together with new experimental techniques, these advances have improved our understanding of membrane protein folding, stability, and recognition. Consequently, new design strategies are emerging that aim to target and stabilize simple transmembrane helical interfaces.
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Authors
Patrick Barth,