Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1979531 | Current Opinion in Structural Biology | 2011 | 13 Pages |
Abstract
The M2 proton channel from influenza A virus, a prototype for a class of viral ion channels known as viroporins, conducts protons along a chain of water molecules and ionizable sidechains, including His37. Recent studies highlight a delicate interplay between protein folding, proton binding, and proton conduction through the channel. Drugs inhibit proton conduction by binding to an aqueous cavity adjacent to M2's proton-selective filter, thereby blocking access of proton to the filter, and altering the energetic landscape of the channel and the energetics of proton-binding to His37.
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Authors
Jun Wang, Jade Xiaoyan Qiu, Cinque Soto, William F DeGrado,