| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1979533 | Current Opinion in Structural Biology | 2011 | 9 Pages |
Abstract
DNA polymerase gamma (Pol γ) is a nuclear encoded, mitochondrially located replicase that conducts all DNA synthesis in the organelle. Structurally, human Pol γ closely resembles bacteriophage T7 DNA polymerase. Perhaps due to this prokaryotic-like feature, Pol γ is highly susceptible to inhibition by drugs designed against HIV reverse transcriptase and HCV RNA polymerase. In this review, I summarize recent structural and biochemical studies towards understanding Pol γ-mediated antiviral drug toxicity.
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Authors
Y. Whitney Yin,