Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1979551 | Current Opinion in Structural Biology | 2008 | 9 Pages |
Abstract
ATP-dependent proteases control diverse cellular processes by degrading specific regulatory proteins. Recent work has shown that protein substrates are specifically transferred to ATP-dependent proteases through different routes. These routes can function in parallel or independently. In all of these targeting mechanisms, it can be useful to separate two steps: substrate binding to the protease and initiation of degradation.
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Authors
Tomonao Inobe, Andreas Matouschek,