Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1979694 | Current Opinion in Structural Biology | 2010 | 9 Pages |
Abstract
Protein interactions give rise to networks that control cell fate in health and disease; selective means to probe these interactions are therefore of wide interest. We discuss here Evolutionary Tracing (ET), a comparative method to identify protein functional sites and to guide experiments that selectively block, recode, or mimic their amino acid determinants. These studies suggest, in principle, a scalable approach to perturb individual links in protein networks.
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Authors
Olivier Lichtarge, Angela Wilkins,