Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1979829 | Current Opinion in Structural Biology | 2006 | 8 Pages |
Abstract
Plants are attractive hosts for the production of recombinant proteins. However, their inability to process authentic human N-glycan structures imposes a major limitation on their use as expression systems for therapeutic products. Several strategies have emerged to engineer plant N-glycans into human-compatible molecules. In this context, fast and reliable analytical strategies for the identification of plant N-glycan profiles have been developed to define the N-glycosylation pathways of crops, to monitor the production of plant-made pharmaceuticals and to assess in planta remodelling strategies.
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Authors
Muriel Bardor, Gleysin Cabrera, Pauline M Rudd, Raymond A Dwek, José A Cremata, Patrice Lerouge,