Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1979868 | Current Opinion in Structural Biology | 2008 | 6 Pages |
Abstract
The extradiol aromatic ring-cleaving dioxygenases activate molecular oxygen by binding both O2 and the catecholic substrate to a reduced active site metal, generally Fe(II). Progress has been made in understanding the mechanism of this reaction through the combined use of kinetic, computational, biomimetic, structural, and diagnostic chemical approaches. It appears that O2 is activated by accepting an electron transferred from the substrate through the metal, thereby simultaneously activating oxygen and substrate for reaction with each other.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
John D Lipscomb,