| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1979878 | Current Opinion in Structural Biology | 2008 | 12 Pages |
Abstract
Eukaryotic fatty acid synthases (FASs) are huge multifunctional enzymes that carry out all enzymatic steps essential for fatty acid biosynthesis. Recent crystallographic studies provide new insights into the architecture of the two distinct eukaryotic FAS systems, the 2.6 MDa heterododecameric fungal and the 540 kDa dimeric animal FAS. In this review, we compare the fundamentally different organization of these two megasynthases and discuss the structural principles of enzyme integration and substrate shuttling in FAS multienzymes.
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Authors
Marc Leibundgut, Timm Maier, Simon Jenni, Nenad Ban,