Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1979881 | Current Opinion in Structural Biology | 2008 | 7 Pages |
Abstract
The recent structure and associated biochemical studies of the metazoan-specific p300/CBP and fungal-specific Rtt109 histone acetyltransferases (HATs) have provided new insights into the ancestral relationship between HATs and their functions. These studies point to a common HAT ancester that has evolved around a common structural framework to form HATs with divergent catalytic and substrate-binding properties. These studies also point to the importance of regulatory loops within HATs and autoacetylation in HAT function. Implications for future studies are discussed.
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Authors
Ling Wang, Yong Tang, Philip A Cole, Ronen Marmorstein,