Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1979905 | Current Opinion in Structural Biology | 2008 | 8 Pages |
Abstract
Current classification systems for protein structure show many inconsistencies both within and between systems. The metafold concept was introduced to identify fold similarities by consensus and thus provide a more unified view of fold space. Using cradle-loop barrels as an example, we propose to use the metafold as the next hierarchical level above the fold, encompassing a group of topologically related folds for which a homologous relationship has been substantiated. We see this as an important step on the way to a classification of proteins by natural descent.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Vikram Alva, Kristin K Koretke, Murray Coles, Andrei N Lupas,