| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1980083 | DNA Repair | 2015 | 7 Pages |
Abstract
Since its discovery, the BRCA1 tumor suppressor has been shown to play a role in multiple DNA damage response pathways. Here, we will review the involvement of BRCA1 in base-excision DNA repair and highlight its clinical implications.
Keywords
PolB Endonuclease IIIOGG1OCT1DNA-PKcsPOLEBARD1EndoIIIFPGXRCC1PNKFEN1MMSPARPBERMMTS8oxoGATRSMUG1PCNApolymerase beta8-oxo-guanine8-oxoguanine DNA glycosylase8-hydroxy-2′-deoxyguanosineapurinic/apyrimidinicataxia telangiectasia mutatedataxia telangiectasia and Rad3 relatedROSHydrogen peroxideProliferating Cell Nuclear Antigenionizing radiationBase-excision repairATMpoldmethyl methanethiosulfonateHomologous recombinationH2O2DNA-dependent protein kinasepoly (ADP-ribose) polymeraseBRCA1breast cancer susceptibility gene 1Reactive oxygen species
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Authors
Elizabeth Alli, James M. Ford,