Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1980339 | DNA Repair | 2012 | 11 Pages |
Abstract
⺠DNA double strand breaks (DSBs) more frequently observed in the TIS21â/â mouse embryo fibroblast. ⺠TIS21 accelerated the repair of DSBs induced by etoposide treatment. ⺠TIS21 strongly inhibited phosphorylations of Chk2T68 and p53S20. ⺠TIS21 bound with PRMT1 and Mre11. ⺠TIS21 accelerated repair of DSBs via increasing Mre11 methylation by enhancing PRMT1 activity.
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Authors
Kyu-Sung Choi, Ji Yeon Kim, Seo-Kyung Lim, Yong Won Choi, Young Hwa Kim, So Young Kang, Tae Jun Park, In Kyoung Lim,