Article ID Journal Published Year Pages File Type
1980399 DNA Repair 2010 8 Pages PDF
Abstract

The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses the requirements for dsb repair in the context of chromatin.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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