| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1980415 | DNA Repair | 2011 | 7 Pages |
Abstract
⺠We report on oxidatively induced DNA damage in colorectal cancer. ⺠We measured the levels of major DNA base lesions in cancerous colorectal tissues and their surrounding normal tissues of patients. ⺠We used mass spectrometry and found significantly lower levels of DNA lesions in cancerous tissues than those in non-cancerous tissues. ⺠Our results suggest that repair of oxidative DNA damage may be up-regulated in colorectal tumors, compared to normal colorectal tissues. ⺠The type of DNA base lesions identified suggests the upregulation of both base excision and nucleotide excision pathways.
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Authors
Güldal Kirkali, Didem Keles, Aras E. Canda, Cem Terzi, Prasad T. Reddy, Pawel Jaruga, Miral Dizdaroglu, Gülgün Oktay,