Article ID Journal Published Year Pages File Type
1980534 DNA Repair 2011 11 Pages PDF
Abstract
▶ AZT causes replication arrest in the bacterium, E. coli. ▶ AZT produces ssDNA gaps. ▶ AZT induces gap-filling recombination reactions. ▶ Exonuclease III is implicated in AZT removal, not proof-reading exonucleases. ▶ AZT is processed to double-strand breaks.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Toxicity and tolerance mechanisms for azidothymidine, a replication gap-promoting agent, in Escherichia coli
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