| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1980818 | DNA Repair | 2008 | 10 Pages |
Abstract
Poly(ADP-ribose) polymerase-1 (PARP-1) is one of the most abundant proteins within mammalian cells. First described more than 45 years ago, PARP-1 has been the subject of many studies and was shown to be involved in multiple aspects of cellular metabolism. Despite many interesting studies that implicate PARP-1 in transcription, chromatin remodelling, apoptosis, DNA repair and several neurological disorders, its precise role is still unclear. This review will discuss the role of PARP-1 in DNA repair and propose a model whereby PARP-1 operates as a modulator of base excision repair capacity.
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Authors
Bethany C. Woodhouse, Grigory L. Dianov,