Article ID Journal Published Year Pages File Type
1981057 DNA Repair 2008 4 Pages PDF
Abstract

The XPD protein is central to our understanding of the relationship between NER deficiencies and human disorders. Three recent papers report the crystal structures of XPD from archaea. Apart from anticipated helicase domains the structures reveal a 4FeS cluster and novel “Arch” domain. The structures help our understanding of genotype–phenotype relationships in the XPD gene.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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