Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1981314 | DNA Repair | 2009 | 8 Pages |
Abstract
Post-translational modification of the cell's proteome by ubiquitin and ubiquitin-like proteins provides dynamic functional regulation. Ubiquitin and SUMO are well-studied post-translational modifiers that typically impart distinct effects on their targets. The recent discovery that modification by SUMO can target proteins for ubiquitination and proteasomal degradation sets a new paradigm in the field, and offers insights into the roles of SUMO and ubiquitin in genome stability.
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Authors
J. Heideker, J.J.P. Perry, M.N. Boddy,