| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1981403 | DNA Repair | 2007 | 7 Pages |
Abstract
This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O6-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.
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Authors
Sankar Mitra,