| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1981453 | DNA Repair | 2007 | 16 Pages |
Abstract
Base excision repair (BER) is the major pathway responsible for averting the mutagenic and cytotoxic effects of spontaneous hydrolytic, oxidative, and non-enzymatic alkylation DNA damage. In particular, this pathway recognizes and repairs base modifications, such as uracil and 8-hydroxyguanine, as well as abasic sites and DNA single-strand breaks. In this review, we outline the basic mechanics of the BER process, and describe the potential association of this pathway with aging and age-related disease, namely cancer and neurodegeneration.
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Authors
David M. Wilson III, Vilhelm A. Bohr,