Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1981487 | DNA Repair | 2006 | 6 Pages |
Abstract
Ubiquitylation is an important regulatory mechanism of many cellular processes. The breast and ovarian cancer-specific tumour suppressor BRCA1 is well acknowledged to be a RING/E3 ubiquitin ligase, however, identification of its physiological substrates has proved elusive. Recently published data have shown that the BRCA1-interacting protein CtIP is in fact ubiquitylated by BRCA1, and opens new avenues for the isolation of other substrate proteins.
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Authors
Louise J. Barber, Simon J. Boulton,