Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1981526 | DNA Repair | 2006 | 4 Pages |
Abstract
In higher eukaryotes, the nuclear lamins play an important role in maintaining the integrity of the nuclear envelope and the nucleus itself. Two recent papers show that a mutation that affects the processing of one of the nuclear lamins, lamin A, results in increased sensitivity to DNA damaging agents, an elevated DNA damage response, and a senescent phenotype. These studies underscore the role of the nuclear envelope in maintaining genomic stability and the interplay between nuclear architechture and the DNA damage response.
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Authors
Susan P. Lees-Miller,