A dodecylamine derivative of cyanocobalamin potently inhibits the activities of cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase of Caenorhabditis elegans

Article ID	Journal	Published Year	Pages	File Type
1981735	FEBS Open Bio	2014	8 Pages	PDF

Abstract

- CN-Cbl dodecylamine, a derivative of cyanocobalamin, was absorbed by C. elegans.
- CN-Cbl dodecylamine decreased activities of cobalamin-dependent enzymes.
- CN-Cbl dodecylamine induced cobalamin deficiency in C. elegans.
- CN-Cbl dodecylamine acts as an inhibitor of cobalamin-dependent enzymes.

Keywords

MCM 5′-deoxyadenosylcobalamin MMAA MMAB MMACHC AdoCbl Methylmalonyl-CoA mutase Cyanocobalamin methylmalonic acid Hcy MMA C. elegans Intrinsic Factor methylcobalamin homocysteine cobalamin Caenorhabditis elegans Cbl