Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1981759 | FEBS Open Bio | 2013 | 6 Pages |
Abstract
⸠l-Rhamnose isomerase catalyzes the reversible isomerization of l-rhamnose to l-rhamnulose. ⸠The catalytic reaction includes opening of the sugar-ring, but the mechanism is unclear. ⸠The structure of the enzyme with substrates in a pyranose ring form was determined. ⸠A catalytic water molecule is probably involved in opening the pyranose ring. ⸠A newly found substrate sub-binding site recognizes the anomers of substrates.
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Authors
Hiromi Yoshida, Akihide Yoshihara, Misa Teraoka, Satoshi Yamashita, Ken Izumori, Shigehiro Kamitori,